Louisa Pili was born in Paris, where at the age of 8 she starred as Mathilde in The Girafe's Neck (Safy Nebbou). Following this first lead role, she appeared at the Comédie Française as Louison in The Imaginery Invalid (Molière, by Claude Stratz). She has also voiced numerous animated films and French dubs. At the age of 15, she runs away to London where she pursued music with the band Black Market Karma. She returned to Paris in 2016, and started acting again. Since has been cast in Papillon (along with Charlie Hunnam and Rami Malek), in the series "The Show" (Directed by Jan Kounen), and appears in Clint Eastwood's The 15:17 To Paris. 
Along with composing music, she has directed two award winning short films and seldom coaches actors in French, English and Italian.